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Unlike many peptide ligands that possess well-characterized receptor targets and signaling pathways, DSIP remains associated with an incompletely defined mechanism of action

Our primary aim was to dissect the role of the incretin peptide hormone GLP-1 in this context by systemically administering GLP-1 and glucose via intraperitoneal injection

Coadministration of glucagon-like peptide-1 during glucagon infusion in humans results in increased energy expenditure and amelioration of hyperglycemia